AI & Computational Biology

Issue 455

Agentic genomics: From pipeline automation to autonomous validation

Issue 439

Contrastive learning unites sequence and structure in a global representation of protein space

Issue 430

Environmental phylogenetics supports a steady diversification of crown eukaryotes starting from the mid-Proterozoic

Issue 425

Bayesian inference of tissue-migration histories in metastatic cancer from cell-lineage tracing data

Issue 417

Landscape of parental postzygotic mutations across >11,000 rare disease trios

Issue 405

On the origin of PRDM9-guided recombination hotspots

Issue 397

SciPhy: A Bayesian phylogenetic framework using sequential genetic lineage tracing data

Issue 394

Benchmarking large language models for cell-free RNA diagnostic biomarker discovery

Issue 377

ProteomeLM: A proteome-scale language model enables accurate and rapid prediction of protein–protein interactions and gene essentiality across taxa

Issue 359

Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor

Issue 351

The persistence and loss of hard selective sweeps amid admixture in ancient Eurasians

Issue 346

How do RNA molecules distinguish self from non-self?

Issue 339

Accessible, realistic genome simulation with selection using stdpopsim

Issue 336

Measuring disease likelihood in genomic ascertainment

Issue 330

Genome-wide detection of human 5′ UTR variants that impact protein translation

Issue 314

Scaling genomic reanalysis to unlock diagnoses and transform rare disease care

Issue 309

A reference panel for linkage disequilibrium and genotype imputation using whole-genome sequencing data from 2,680 participants across India

Issue 304

Signatures of sex ratio distortion in humans

Issue 293

Leveraging protein language models and a scoring function for indel characterization and transfer learning

Issue 279

Against the Uncritical Adoption of AI Technologies in Academia

Issue 258

Genomic GC bias correction improves species abundance estimation from metagenomic data

Issue 236

Translocation mechanism of xeroderma pigmentosum group D protein on single-stranded DNA and genetic disease etiology

Issue 215

Protein Set Transformer: a protein-based genome language model to power high-diversity viromics

Issue 207

Semantic design of functional de novo genes from a genomic language model

Issue 194

Issue 188

Issue 162

Spatially resolved microRNA expression in tissues: technologies, challenges, and opportunities

Issue 151

External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium

Issue 150

Patrilineal segmentary systems provide a peaceful explanation for the post‑Neolithic Y‑chromosome bottleneck

Issue 144

Revised time estimation of the ancestral human chromosome 2 fusion

Issue 111

A multimodal dataset for precision oncology in head and neck cancer

Issue 064

Pisces: A multi-modal data augmentation approach for drug combination synergy prediction

Issue 060

Improving polygenic prediction from whole-genome sequencing data by leveraging predicted epigenomic features

Issue 039

Toward whole-genome inference of polygenic scores with fast and memory-efficient algorithms

Issue 009

Bayesian causal graphical model for joint Mendelian randomization analysis of multiple exposures and outcomes

Issue 005

Genome-wide nucleosome footprints of plasma cfDNA predict preterm birth: A case-control study