Base by Base

Browse by Topic

Every episode is built from a primary, open-access research paper. Explore the collection by theme.

Cancer & Oncology 84 episodes

Episodes on cancer genomics, tumor biology, liquid biopsy, and therapy resistance — drawn from primary research papers.

Population & Evolutionary Genetics 126 episodes

Episodes on GWAS, ancient DNA, human population history, polygenic risk, and natural selection.

Sequencing Methods & Technologies 165 episodes

Episodes on the tools of modern genomics: single-cell, long-read, spatial omics, cryo-EM, prime editing and CRISPR.

RNA Biology & Splicing 66 episodes

Episodes on splicing, noncoding RNA, transcription and the many roles of RNA in the cell.

Neuroscience & Neurodevelopment 75 episodes

Episodes on the brain, neurodevelopmental disorders, and the genetics of the nervous system.

Rare & Mendelian Diseases 61 episodes

Episodes on inherited disorders, variant interpretation, and the path from genotype to diagnosis.

Epigenetics & Gene Regulation 48 episodes

Episodes on DNA methylation, chromatin, transcription factors and how genes are switched on and off.

Mitochondria & Metabolism 68 episodes

Episodes on mitochondrial genetics, metabolism, and metabolic disease.

Microbiome & Infectious Disease 69 episodes

Episodes on the microbiome, pathogens, viruses and the genomics of infection.

AI & Computational Biology 34 episodes

Episodes on machine learning, computational methods, and data-driven discovery in biology.

Genomics & Genetics 44 episodes

Episodes across genomics and genetics that span multiple themes.

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