Cancer & Oncology

Issue 425

Bayesian inference of tissue-migration histories in metastatic cancer from cell-lineage tracing data

Issue 421

Pre-existing cell states predict resistance to multiple treatments

Issue 419

The Single-Cell Pediatric Cancer Atlas: Data portal and open-source tools for single-cell transcriptomics of pediatric tumors

Issue 415

A ligandable PNT domain establishes ERG as a directly targetable oncogenic driver in prostate cancer

Issue 403

Homologous recombination deficiency-driven genomic instability in ovarian cancer as an indicator of BRCA1 and BRCA2 variant pathogenicity

Issue 389

Crotonylation impedes c-Myc oncogenic activity

Issue 386

Polyploidy: A macromutational force pushing bioeconomic developments

Issue 380

A multiplex, prime editing framework for identifying drug resistance variants at scale

Issue 370

ICMT supports BRAF ^V600E -driven tumor growth by membrane targeting of the CAAX protein INPP5E

Issue 369

NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma

Issue 366

Regulation of antiviral and antitumor immunity by the BRCA1 pseudogene in human cancers

Issue 365

CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials

Issue 363

Cell-free DNA size deconvolution resolves nucleosomal origins and reveals tumor-associated fragmentomic alterations

Issue 348

A plasma - based DNA test for quantification of disease burden in acute myeloid leukemia patients undergoing bone marrow transplantation

Issue 336

Measuring disease likelihood in genomic ascertainment

Issue 333

Holistic determination of ends of cfDNA molecules

Issue 330

Genome-wide detection of human 5′ UTR variants that impact protein translation

Issue 319

Characteristics predicting reduced penetrance variants in the high-risk cancer predisposition gene TP53

Issue 311

When alternative becomes essential: The role of mitochondrial glycerol-3-phosphate dehydrogenase

Issue 296

Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations

Issue 276

Advancing regulatory variant effect prediction with AlphaGenome

Issue 273

Horizontal transfer of nuclear DNA in transmissible cancer

Issue 264

Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation

Issue 258

Genomic GC bias correction improves species abundance estimation from metagenomic data

Issue 252

Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma

Issue 250

The CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJ

Issue 247

Genome graphs reveal the importance of structural variation in Mycobacterium tuberculosis evolution and drug resistance

Issue 231

Transcription start sites experience a high influx of heritable variants fueled by early development

Issue 226

FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice

Issue 222

Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations

Issue 220

The AML cellular state space unveils NPM1 immune evasion subtypes with distinct clinical outcomes

Issue 212

Nature | www.nature.com | 1

Issue 211

Genetic elements promote retention of extrachromosomal DNA in cancer cells

Issue 210

Tumour-reactive heterotypic CD8 T cell clusters from clinical samples

Issue 204

StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models

Issue 203

Divergent Evolutionary Dynamics of Benign and Malignant Tumors

Issue 201

Sex and smoking bias in the selection of somatic mutations in human bladder

Issue 198

Mechanical confinement governs phenotypic plasticity in melanoma

Issue 187

Tumor-targeted top1 inhibitor delivery with optimized parp inhibition in advanced solid tumors: a phase i trial of gapped scheduling

Issue 184

Issue 177

Issue 176

Issue 151

External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium

Issue 148

Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants

Issue 146

Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA for Identification of Targetable and Resistance Alterations in Advanced Solid Tumors

Issue 145

A Validated Highly Sensitive Microsatellite Instability Assay Accurately Identifies Individuals Harboring Biallelic Germline PMS2 Pathogenic Variants in Constitutional Mismatch Repair Deficiency

Issue 139

MosCoverY: A method to estimate mosaic loss of Y chromosome from sequencing coverage data

Issue 136

Gene context drift identifies drug targets to mitigate cancer treatment resistance

Issue 134

Single-cell analysis of Barrett’s esophagus and carcinoma reveals cell types conferring risk via genetic predisposition

Issue 132

Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers

Issue 127

In silico generation of synthetic cancer genomes using generative AI

Issue 122

Patient stratification reveals the molecular basis of disease co- occurrences

Issue 121

G-quadruplexes as a source of vulnerability in BRCA2-deficient granule cell progenitors and medulloblastoma

Issue 118

Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

Issue 115

A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system

Issue 114

One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique

Issue 111

A multimodal dataset for precision oncology in head and neck cancer

Issue 109

Issue 105

Genome-level selection in tumors as a universal marker of resistance to therapy

Issue 100

Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia

Issue 097

Issue 094

Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer

Issue 087

Circulating cell-free DNA methylation patterns indicate cellular sources of allograftinjury after liver transplant

Issue 085

Genomic landscape of virus-associated cancers

Issue 082

JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms

Issue 069

Three independent approaches identify IGF2BP2 as a top SDL target of PLK1

Issue 066

Mainstreaming of clinical genetic testing: A conceptual framework

Issue 064

Pisces: A multi-modal data augmentation approach for drug combination synergy prediction

Issue 062

BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function

Issue 060

Improving polygenic prediction from whole-genome sequencing data by leveraging predicted epigenomic features

Issue 059

Optimizing participant and community engagement in cancer genomic sequencing research

Issue 058

Depletion of aneuploid cells is shaped by cell-to-cell interactions

Issue 053

Weighing the evidence on costs and benefits of polygenic risk-based approaches in clinical practice: A systematic review of economic evaluations

Issue 050

The microbiome for clinicians

Issue 048

Mainstreaming of clinical genetic testing: A conceptual framework

Issue 046

tRNA modifications tune m6A-dependent mRNA decay

Issue 044

The proofreading mechanism of the human leading-strand DNA polymerase ε holoenzyme

Issue 033

Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias

Issue 026

Reannotation of cancer mutations based on expressed RNA transcripts reveals functional non-coding mutations in melanoma

Issue 023

Evaluating the return of additional findings from the 100,000 Genomes Project: A mixed methods study exploring participant experiences of receiving secondary findings from genomic sequencing

Issue 012

Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair

Issue 005

Genome-wide nucleosome footprints of plasma cfDNA predict preterm birth: A case-control study

Issue 002

Impact of Tube Additives on Baseline Cell-Free DNA, Blood Nuclease Activity, and Cell-Free DNA Degradation in Serum and Plasma Samples: A Comparative Study

Issue 001

ACMG/AMP interpretation of BRCA1 missense variants: Structure-informed scores add evidence strength granularity to the PP3/BP4 computational evidence