Epigenetics & Gene Regulation

Issue 420

Genetic diversity and regulatory features of human-specific NOTCH2NL duplications

Issue 415

A ligandable PNT domain establishes ERG as a directly targetable oncogenic driver in prostate cancer

Issue 400

Complete chromosome 21 centromere sequencing of families with Down syndrome

Issue 389

Crotonylation impedes c-Myc oncogenic activity

Issue 382

Animals have expanded the evolutionary legacy of unicellular ancestors in blood cells

Issue 381

Spatially tuneable multiomic sequencing using light-driven combinatorial barcoding of molecules in tissues

Issue 371

Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states

Issue 367

Ancestral splice variation is a key substrate for rapid diversification in African cichlids

Issue 354

Cohesin acetylation and ATPase activity control cohesion and loop architecture through distinct mechanisms

Issue 346

How do RNA molecules distinguish self from non-self?

Issue 342

Using a modular massively parallel reporter assay to discover context-dependent regulatory activity in type 2 diabetes-linked noncoding regions

Issue 333

Holistic determination of ends of cfDNA molecules

Issue 332

Chromatin accessibility regulates age- dependent nuclear mechanotransduction

Issue 305

Functional dissection of complex trait variants at single-nucleotide resolution

Issue 294

The splice of life: how alternative splicing shapes regulatory and phenotypic evolution

Issue 287

EPOP and MTF2 activate PRC2 activity through DNA-sequence specificity

Issue 276

Advancing regulatory variant effect prediction with AlphaGenome

Issue 264

Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation

Issue 262

Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission

Issue 256

Chromosome compartment assembly is essential for subtelomeric gene silencing in trypanosomes

Issue 253

Roles of histone chaperone Nap1 and histone acetylation in regulating phase-separation of nucleosome arrays

Issue 250

The CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJ

Issue 241

Insights into natural neocentromere evolution from a cattle T2T X chromosome

Issue 235

Maternal histone methyltransferases antagonistically regulate autosomal random monoallelic expression (aRMAE) in C. elegans

Issue 233

Mechanistic insights into histone recognition and H3K14 acetylation by the NuA3 histone acetyltransferase complex

Issue 232

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Issue 225

BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity

Issue 222

Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations

Issue 221

An allele-resolved nanopore-guided tour of the human placental methylome

Issue 213

BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants

Issue 211

Genetic elements promote retention of extrachromosomal DNA in cancer cells

Issue 198

Mechanical confinement governs phenotypic plasticity in melanoma

Issue 196

Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts

Issue 192

Issue 189

Issue 175

Issue 127

In silico generation of synthetic cancer genomes using generative AI

Issue 124

Exploring the omnigenic architecture of selected complex traits

Issue 110

Whole-exome sequencing analysis identifies risk genes for schizophrenia

Issue 108

Removal of promoter CpG methylation by epigenome editing reverses HBG silencing

Issue 100

Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia

Issue 094

Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer

Issue 087

Circulating cell-free DNA methylation patterns indicate cellular sources of allograftinjury after liver transplant

Issue 080

Genome sequencing is critical for forecasting outcomes following congenital cardiacsurgery

Issue 077

Range extender mediates long-distance enhancer activity

Issue 070

Scalable screening of ternary-code DNA methylation dynamics associated with human traits

Issue 028

scPrediXcan integrates deep learning methods and single-cell data into a cell-type-specific transcriptome-wide association study framework

Issue 001

ACMG/AMP interpretation of BRCA1 missense variants: Structure-informed scores add evidence strength granularity to the PP3/BP4 computational evidence