Microbiome & Infectious Disease

Issue 431

Identification of a conserved gene family with an essential role in Leishmania parasite–insect vector adhesion

Issue 411

A scalable, dividing cell model for the robust propagation and quantification of human sporadic Creutzfeldt–Jakob disease prions

Issue 409

A systems-level atlas of carbon-response transcriptional states in Escherichia coli

Issue 407

SLC11A2 withholds divalent metals from Salmonella in the gut epithelium

Issue 406

Temperature and developmental stage govern intestinal susceptibility to human coronavirus 229E

Issue 403

Homologous recombination deficiency-driven genomic instability in ovarian cancer as an indicator of BRCA1 and BRCA2 variant pathogenicity

Issue 395

Extended sequence context shapes mutational bias in Escherichia coli

Issue 393

Targeted next-generation sequencing implementation in Eswatini identifies rifampicin and bedaquiline resistance undetected by routine diagnostic testing

Issue 390

DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity

Issue 387

Long-term antibody dynamics challenge the paradigm of lifelong homotypic immunity to dengue virus

Issue 384

A 3’UTR-derived small RNA modulates the life cycle of the cholera toxin–encoding filamentous phage, CTXϕ

Issue 369

NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma

Issue 362

D614G reshapes allosteric networks and opening mechanisms of SARS - CoV - 2 spikes

Issue 359

Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor

Issue 355

Efficient replication of influenza D virus in the human airway underscores zoonotic potential

Issue 352

Interspecies interaction controls Escherichia coli growth in human gut microbiome samples

Issue 343

Distinct evolutionary patterns of endemic and emerging parvoviruses and the origin of a new pandemic virus

Issue 324

The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation

Issue 320

Sex-stratified genetic regulators of cytokine production in the Dutch and Tanzanian populations

Issue 315

Capturing dynamic phage–pathogen coevolution by clinical surveillance

Issue 310

Infant gut microbiota restoration: state of the art

Issue 307

A membrane-bound nuclease directly cleaves phage DNA during genome injection

Issue 303

The untapped potential of short-read sequencing in biodiversity research

Issue 300

Population-scale sequencing resolves determinants of persistent EBV DNA

Issue 295

Cystic fibrosis risk variants confer protection against inflammatory bowel disease

Issue 293

Leveraging protein language models and a scoring function for indel characterization and transfer learning

Issue 286

Functional and antigenic constraints on the Nipah virus fusion protein

Issue 266

Differential roles of type I topoisomerases in regulating HPV pathogenesis

Issue 263

A pothole-filling strategy for selective targeting of rCUG-repeats associated with myotonic dystrophy type 1

Issue 262

Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission

Issue 259

Oligomerisation of Ku from Mycobacterium tuberculosis promotes DNA synapsis

Issue 258

Genomic GC bias correction improves species abundance estimation from metagenomic data

Issue 254

Rescuing the bacterial replisome at a nick requires recombinational repair and helicase reloading

Issue 245

Benchmarking DNA foundation models for genomic and genetic tasks

Issue 242

Gene therapy delivery of anti‑Müllerian hormone in prepubertal female domestic cats induces long-term sterilization.

Issue 237

Using metagenomics and whole-genome sequencing to characterize enteric pathogens across various sources in Africa

Issue 234

MTHFR allele and one-carbon metabolic profile predict severity of COVID-19

Issue 224

Wireless in-body sensing through genetically engineered bacteria

Issue 215

Protein Set Transformer: a protein-based genome language model to power high-diversity viromics

Issue 206

Ecology and spread of the North American H5N1 epizootic

Issue 202

Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution

Issue 186

Issue 171

Virulence hierarchies within the Mycobacterium tuberculosis complex

Issue 145

A Validated Highly Sensitive Microsatellite Instability Assay Accurately Identifies Individuals Harboring Biallelic Germline PMS2 Pathogenic Variants in Constitutional Mismatch Repair Deficiency

Issue 142

Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline PALB2 sequence variants

Issue 140

Landscapes of missense variant impact for human superoxide dismutase 1

Issue 137

Rethinking RNA-binding proteins: Riboregulation challenges prevailing views

Issue 133

Culture-independent meta-pangenomics enabled by long-read metagenomics reveals associations with pediatric undernutrition

Issue 131

A cryptic plasmid is among the most numerous genetic elements in the human gut

Issue 117

Issue 107

Genome-wide association study of pulpal and apical diseases

Issue 093

Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease

Issue 085

Genomic landscape of virus-associated cancers

Issue 084

Variants in NR6A1 cause a novel oculo vertebral renal syndrome

Issue 074

Benchmarking of T cell receptor-epitope predictors with ePytope-TCR

Issue 071

ELFN1 Deficiency: the mechanistic basis and phenotypic spectrum of a neurodevelopmental disorder with epilepsy

Issue 068

Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations

Issue 054

Temporal multi-omics analysis of COVID-19 in end-stage kidney disease

Issue 052

Human genetic variation reveals FCRL3 is a lymphocyte receptor for Yersinia pestis

Issue 050

The microbiome for clinicians

Issue 049

Environmental DNA adsorption to chitin can promote horizontal gene transfer by natural transformation

Issue 047

Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network

Issue 038

The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2

Issue 037

Prioritizing disease-associated missense variants with chemoproteomic-detected amino acids

Issue 027

Engineered nucleocytosolic vehicles for loading of programmable editors

Issue 012

Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair

Issue 010

Consensus guidelines for assessing eligibility of pathogenic DNA variants for antisense oligonucleotide treatments

Issue 006

Bi-allelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a neurodevelopmental disorder

Issue 001

ACMG/AMP interpretation of BRCA1 missense variants: Structure-informed scores add evidence strength granularity to the PP3/BP4 computational evidence