Mitochondria & Metabolism

Issue 433

HSP90α lactylation orchestrates PGC1α and LRPGC1 nuclear translocation driving mitochondrial biogenesis

Issue 428

Genome-wide association study of untargeted plasma metabolomic profiles identifies host genetic regulation in people with HIV

Issue 427

The gut microbiome as an effector of metabolic disease gene variants

Issue 409

A systems-level atlas of carbon-response transcriptional states in Escherichia coli

Issue 408

Tau protein as a regulator of mitochondrial function and dynamics

Issue 391

The Kaufmann Protocol: Why We Age and How to Stop It

Issue 388

mRNA‑laden LNP‑enabled in situ CAR‑macrophage alleviates liver fibrosis via inhibiting activated HSCs and modulating the immune microenvironment

Issue 385

Growth under pressure: The pros and cons of polyploidy induced by stress

Issue 376

Regulation of Pfh1 helicase activity by nucleic acid interactions and mitochondrial SSB

Issue 358

Biallelic variants in CHCHD4 are associated with combined OXPHOS defect leading to mitochondrial disease

Issue 356

Meta-analysis across six global biobanks identifies recessive coding associations with complex traits and diseases

Issue 350

Rhesus macaques with an OPA1 mutation demonstrate features of autosomal dominant optic atrophy

Issue 349

Structural basis of transcription -coupled RNA damage by incorporation of oxidized ribonucleotides

Issue 347

Diffusive spreading across dynamic mitochondrial network architectures

Issue 342

Using a modular massively parallel reporter assay to discover context-dependent regulatory activity in type 2 diabetes-linked noncoding regions

Issue 337

Neurodevelopmental copy-number variants increase risk of internalizing and cardiometabolic multimorbidity: Findings from the UK Biobank

Issue 332

Chromatin accessibility regulates age- dependent nuclear mechanotransduction

Issue 331

Bi-allelic variants in NDUFA5 cause a mitochondriopathy with complex I deficiency

Issue 327

Bi-allelic ATG12 variants impair autophagy and cause a neurodevelopmental disorder

Issue 322

Bi-allelic variants in the non-protein-coding minor spliceosome components RNU6ATAC and RNU4ATAC cause syndromic monogenic autoimmune diabetes

Issue 313

Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research

Issue 312

Mfsd2a is important for maintaining epidermal homeostasis

Issue 308

Conserved shifts in sperm small non-coding RNA profiles during mouse and human aging

Issue 301

Leveraging large-scale biobanks for therapeutic target discovery

Issue 292

A new form of diabetes caused by INS mutations defined by zygosity, stem cell and population data

Issue 291

Dated gene duplications elucidate the evolutionary assembly of eukaryotes

Issue 282

A gene-specific variance-control approach corrects polygenicity-driven inflation observed in transcriptome-wide association studies

Issue 274

RPE- specific MCT2 expression promotes cone survival in models of retinitis pigmentosa

Issue 264

Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation

Issue 257

Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies

Issue 255

Impact of anionic lipids on the energy landscape of conformational transition in anion exchanger 1 (AE1)

Issue 248

Disruption of the PIKfyve complex unveils an adaptive mechanism to promote lysosomal repair and mitochondrial homeostasis

Issue 244

NEK7 couples SDHB to orchestrate respiratory chain electron transport homeostasis that impedes liver fibrosis

Issue 243

Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure

Issue 240

CYFIP1 governs the development of cortical axons by modulating calcium availability

Issue 239

The Genomic Basis of the Svalbard Reindeer’s Adaptation to an Extreme Arctic Environment

Issue 234

MTHFR allele and one-carbon metabolic profile predict severity of COVID-19

Issue 229

Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer’s disease

Issue 219

Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in Parkinson’s disease brain

Issue 218

Multi-ancestry investigation of the genomics of erectile dysfunction

Issue 214

Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2

Issue 205

Ancient RNA expression profiles from the extinct woolly mammoth

Issue 190

Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes

Issue 190

Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes

Issue 169

Deep mutational scanning of the human insulin receptor ectodomain to inform precision therapy for insulin resistance

Issue 153

Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits

Issue 141

RetiGene, a comprehensive gene atlas for inherited retinal diseases

Issue 138

Social exposome and brain health outcomes of dementia across Latin America

Issue 137

Rethinking RNA-binding proteins: Riboregulation challenges prevailing views

Issue 132

Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers

Issue 130

Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution

Issue 123

Dominant negative ATP5F1A variants disrupt oxidative phosphorylation causing neurological disorders

Issue 116

Cell type–specific purifying selection of synonymous mitochondrial DNA variation

Issue 107

Genome-wide association study of pulpal and apical diseases

Issue 095

Biotechnological approaches and therapeutic potential of mitochondria transfer and transplantation

Issue 088

Stable heritability of type 1 diabetes in a Swedish Nationwide Cohort Study

Issue 086

Investigating the sources of variable impact of pathogenic variants in monogenic metabolic conditions

Issue 078

Interactions between TTYH2 and APOE facilitate endosomal lipid transfer

Issue 075

The role of metabolism in shaping enzyme structures over 400 million years

Issue 072

Bi-allelic loss-of-function variants in POC5 cause a syndromic retinal, endocrine and neuromuscular ciliopathy

Issue 070

Scalable screening of ternary-code DNA methylation dynamics associated with human traits

Issue 056

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

Issue 055

Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium

Issue 051

Mitochondrial DNA disease discovery through evaluation of genotype and phenotype data: The Solve-RD experience

Issue 043

Personalized molecular signatures of insulin resistance and type 2 diabetes

Issue 034

Safety and efficacy of pegtibatinase enzyme replacement therapy in adults with classical homocystinuria in the COMPOSE phase 1/2 randomized trial

Issue 025

Mitochondrial DNA disease discovery through evaluation of genotype and phenotype data: The Solve-RD experience

Issue 011

Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis