RNA Biology & Splicing

Issue 422

Germline sequence variation within the ribosomal DNA is associated with human complex traits

Issue 418

Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging

Issue 407

SLC11A2 withholds divalent metals from Salmonella in the gut epithelium

Issue 406

Temperature and developmental stage govern intestinal susceptibility to human coronavirus 229E

Issue 392

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats

Issue 388

mRNA‑laden LNP‑enabled in situ CAR‑macrophage alleviates liver fibrosis via inhibiting activated HSCs and modulating the immune microenvironment

Issue 384

A 3’UTR-derived small RNA modulates the life cycle of the cholera toxin–encoding filamentous phage, CTXϕ

Issue 383

Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome

Issue 368

PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer’s disease model

Issue 367

Ancestral splice variation is a key substrate for rapid diversification in African cichlids

Issue 364

Peripheral complement C4 protein in schizophrenia: Association with gene copy number and immune cell subtypes

Issue 350

Rhesus macaques with an OPA1 mutation demonstrate features of autosomal dominant optic atrophy

Issue 340

Alternative microexon splicing code for a four - amino acid peptide of PTPRD governs behavioral development

Issue 338

Bi-allelic WDHD1 variants cause microcephalic primordial dwarfism

Issue 334

Comparative genomics reveals LINE-1 recombination with diverse RNAs

Issue 333

Holistic determination of ends of cfDNA molecules

Issue 330

Genome-wide detection of human 5′ UTR variants that impact protein translation

Issue 324

The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation

Issue 322

Bi-allelic variants in the non-protein-coding minor spliceosome components RNU6ATAC and RNU4ATAC cause syndromic monogenic autoimmune diabetes

Issue 318

Biallelic Variants in RNU6ATAC Result in a Minor Spliceopathy Characterized by Transcriptome-Wide Minor Intron Retention Events and Short Stature with Variable Multisystem Manifestations

Issue 317

Overlap between COPD genetic association results and transcriptional quantitative trait loci

Issue 308

Conserved shifts in sperm small non-coding RNA profiles during mouse and human aging

Issue 305

Functional dissection of complex trait variants at single-nucleotide resolution

Issue 302

The Last Exon Light: A Tribute Dossier Celebrating the Scientific Career of Prof. Dr. Brunhilde Wirth

Issue 299

Encephalopathy-linked UFM1 variants impede neuronal protein translation, development, and function

Issue 298

Bi-allelic variants in FSD1L cause retinitis pigmentosa with or without neurological involvement

Issue 296

Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations

Issue 294

The splice of life: how alternative splicing shapes regulatory and phenotypic evolution

Issue 290

SMN1 variants identified by false-positive SMA newborn screening tests: Therapeutic hurdles and functional and epidemiological solutions

Issue 279

Against the Uncritical Adoption of AI Technologies in Academia

Issue 276

Advancing regulatory variant effect prediction with AlphaGenome

Issue 265

Deep evolutionary conservation of a sex-determining locus without sequence homology

Issue 263

A pothole-filling strategy for selective targeting of rCUG-repeats associated with myotonic dystrophy type 1

Issue 246

Structural pharmacology of SV2A reveals an allosteric modulation mechanism in the major facilitator superfamily

Issue 240

CYFIP1 governs the development of cortical axons by modulating calcium availability

Issue 229

Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer’s disease

Issue 226

FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice

Issue 222

Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations

Issue 212

Nature | www.nature.com | 1

Issue 208

ZAK activation at the collided ribosome

Issue 205

Ancient RNA expression profiles from the extinct woolly mammoth

Issue 202

Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution

Issue 190

Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes

Issue 164

m6A in the coding sequence: linking deposition, translation, and decay

Issue 162

Spatially resolved microRNA expression in tissues: technologies, challenges, and opportunities

Issue 160

Single-cell omics sequencing technologies: the long-read generation

Issue 160

Single-cell omics sequencing technologies: the long-read generation

Issue 148

Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants

Issue 142

Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline PALB2 sequence variants

Issue 137

Rethinking RNA-binding proteins: Riboregulation challenges prevailing views

Issue 119

G- quadruplex stabilization induces DNA breaks in pericentromeric repetitive DNA sequences in B lymphocytes

Issue 113

Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Issue 092

Loss of CFHR5 function reduces the risk for age-related macular degeneration

Issue 069

Three independent approaches identify IGF2BP2 as a top SDL target of PLK1

Issue 065

Utility of genome sequencing and group-enrichment to support splice variant interpretation in Marfan syndrome

Issue 062

BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function

Issue 050

The microbiome for clinicians

Issue 046

tRNA modifications tune m6A-dependent mRNA decay

Issue 045

Micropipette aspiration reveals differential RNA-dependent viscoelasticity of nucleolar subcompartments

Issue 033

Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias

Issue 031

Utility of genome sequencing and group-enrichment to support splice variant interpretation in Marfan syndrome

Issue 022

Ribonuclease activity undermines immune sensing of naked extracellular RNA

Issue 021

High-throughput screening of human genetic variants by pooled prime editing

Issue 016

Advancing equity in human genomics through tissue-specific multi-ancestry molecular data

Issue 010

Consensus guidelines for assessing eligibility of pathogenic DNA variants for antisense oligonucleotide treatments

Issue 003

Data-driven insights to inform splice-altering variant assessment