This episode examines an international cohort of 18 individuals with de novo or loss-of-function variants in EIF3A or EIF3B who present with congenital heart defects, craniofacial differences, and mild neurodevelopmental features, and reviews zebrafish CRISPR models that recapitulate key aspects of the human phenotype.
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This episode examines an international cohort of 18 individuals with de novo or loss-of-function variants in EIF3A or EIF3B who present with congenital heart defects, craniofacial differences, and mild neurodevelopmental features, and reviews zebrafish CRISPR models that recapitulate key aspects of the human phenotype.
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QC Report
The paper, claim by claim.
Every episode is audited against the original paper before publication. Numbers, mechanisms, and verbal claims are checked one by one.
Original composition
When the Start Signal Fades
Inspired by A cardiovascular, craniofacial, and neurodevelopmental disorder caused by loss-of-function variants in the eIF3 complex component genes EIF3A and EIF3B
Style sheet
Genre Minimalist pulse (Reich-inspired) Tempo 128 BPM Key A minor
